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Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate

For RA or JIA: Your symptoms, such as inflammation and pain, may not go away or may get worse

Vitamin B12 enhances these effects by contributing to the production of red blood cells and improving oxygen delivery throughout the body, which supports endurance and energy expenditure

In the absence of impaired kidney function, an elevated MMA level in conjunction with elevated homocysteine suggests either a vitamin B 12 deficiency or a combined vitamin B 12 and folate deficiency (32)

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