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Transgenic mice were maintained in a mixed background of C57BL/6 and SV129
By activating AMPK, GSK621 was shown to be able to cause immunogenic cell death in AML cells, hence enhancing anti-tumor immune responses

Indeed, under stress conditions, it was demonstrated that in the endoplasmic reticulum, both alterations occur in calcium homeostasis and the accumulation of misfolded proteins, with consequent activation of unfolded protein response pathway
Allergy 34:103110

The 26S proteasome is a 2.5MDa multiprotein complex found in all eukaryotic cells