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APOE4 carriers exhibit increased BBB permeability in vitro and in vivo, as demonstrated through diverse approaches, including MRI-based imaging, biomarker analyses, and an induced pluripotent stem cell (iPSC) three-dimensional model, whereas studies on postmortem brain tissue have revealed pericyte loss or vascular degeneration linked to APOE4-driven neuroinflammation [106,107]

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Reoperative Pulmonary Endarterectomy: Past Failures of Patient Selection Can Assist in Future Practice of Informed Consent