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In terms of adverse effects, palbociclib is more likely to cause neutropenia compared to ribociclib and abemaciclib [21]
Although systemic inflammation is known to modulate iron metabolism, such as interleukin-6 (IL-6) stimulating hepcidin synthesis and subsequently downregulating FPN1, this has been observed primarily in hepatic tissues (95)
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, Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence
doi: 10.1016/j.abb.2009.03.001
