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2018;50:e12874

[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Tang T.-H., Bachellerie J.-P., Rozhdestvensky T., Bortolin M.-L., Huber H., Drungowski M., Elge T., Brosius J., Httenhofer A

Both RFK and FLAD1 reside in the cytosol and within mitochondria, allowing newly formed FAD to accumulate in the mitochondrial matrix, where it serves as an essential co-factor for numerous flavoproteinsincluding ETF-DH, AIFM1, multiple acyl-CoA dehydrogenases, and glutathione reductase (Figure 1) (60)

Furthermore, because of the tumor heterogeneity in HCC, it is reasonable that the diversified activation of the Wnt pathway could exist in tumor nodules, which results in more intricate Wnt signaling in response to variant stress, TKI treatment, and immunotherapy

OXIDATIVE STRESS, INSULIN SIGNALING AND DIABETES Hristov, B.D