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* p .05, ** p .01, *** p .001, **** p .0001 vs

TBARS: thiobarbituric acid reactive substances

121123 For example, the YMD@MPDA nanocomposite clears ROS and releases H 2 S through MnO 2 , inhibits the NOX4 and p38 MAPK pathways, and promotes the polarization of macrophages toward the M2 phenotype, thereby alleviating inflammation and remodeling the immune microenvironment

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Although human nitrate reductase activity has been posited as a secondary function of xanthine oxidase (XO, vide infra ), especially for organic nitrates (RONO 2 ) (Millar et al ., 1998