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Description
83 Each protomer of this homodimeric transporter comprises nine transmembrane helices and three metal ions
Insect iron binding proteins: Insights from the genomes
Inzucchi, S
In the absence of intracellular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) not only reacts with nucleophilic groups of cellular proteins resulting in direct hepatocellular damage, but also participates in redox cycling, thereby generating reactive O 2 species ( ROS ) and consequent oxidative stress that greatly enhance APAP-induced hepatotoxicity
The rate of recurrence can reach 60% [23]
