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There are many conditions that may worsen from sauna or are just plain contraindicated

(1999b)

doi: 10.1016/j.cell.2017.09.045 87 LeeW-HNajjarSMKahnCRHindsTD

Consistent with this general mechanism, oxidative stress is a major proposed pathogenic mechanism for neurodegenerative disorders in which mitochondrial defects have been reported, including Parkinsons, Huntingtons, and Alzheimers diseases

this pathway will, in turn, upregulate pro-fibrogenic matrix metalloproteinase-2 (MMP2) and downregulate matrix metalloproteinase-1 (MMP1), two enzymes responsible for remodeling the hepatic extracellular matrix [9, 191, 192, 216]