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As the products of the SAHH-catalysed cleavage are rapidly removed in vivo, this reaction is preferred in cells, while SAH synthesis is the main reaction taking place in vitro 21,22

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If your research requires absolutely clean IGF-1R-specific signalling without any insulin receptor cross-reactivity, DES is theoretically superior

When a compound is used across several readout families, the value of a consistent dispensing format and documented specifications increases because it helps laboratories attribute differences to experimental variables rather than preparation drift
