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ADD3 mutations disrupt afferent arteriole contractility by interfering with the actin cytoskeletal architecture, resulting in a loss of myogenic tone and increased glomerular capillary pressure, ultimately resulting in proteinuria and glomerulosclerosis in FHH rats

Vitamin B12 plays a role in producing brain chemicals, such as serotonin, that help control mood and other brain functions

Zhang J, Liu D, Zhang M, Zhang Y

Systematic substitution of each residue in the sequence with Ala enables the identification of critical amino acids governing protein bioactivity