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If you find your energy levels are low or you are entering a period of high stress, you might temporarily increase your dose

Depletion of bioavailable nitric oxide in the vasculature by excess oxidants causes endothelial dysfunction, which is characterized by a decrease in endothelium-dependent vasodilation while retaining the ability of vascular smooth muscle cells to vasodilate in response to nitric oxide donors, such as sodium nitroprusside [53]

This growing prevalence has made infertility a significant public health concern (Herweck et al., 2025)
