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These signs are not specific and other causes should always be ruled out while considering the clinical context
For example, knockdown of ADPribose PARP1 in skeletal muscle ncreases PGC-1 and PINK1 expression, downregulates ADPribosylation of AMPK, and increases AMPK activity, leading to accelerated mitochondrial turnover, increased mitochondrial biogenesis, and improved skeletal muscle metabolism, ultimately extending lifespan
Br J Opthalmol
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