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Pyruvate kinase deficiency is characterized by molecular as well as clinical heterogeneity

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Furthermore, with respect to dopaminergic signaling, a reduction in anxiety-like behaviors and an increase in locomotor activity in 3xTg mice are accompanied by an increase in postsynaptic D2 dopamine receptors in the striatum and in D2-autoreceptors in substantia nigra/VTA cell bodies (Gloria et al., 2021)