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GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
doi: 10.5114/wo.2014.47131 24 PietrzakSWjcikJScottRJKashyapAGrodzkiTBaszukPet al
Depleted levels of glutathione are recognized to result in susceptibility to cellular deterioration, as a result of multiple circumstances, including oxidative stress, free radical exposure, infections, and toxins.
Most importantly, design studies to answer mechanistic questions (does the peptide activate the expected pathway?) before efficacy questions (does it improve venous function?)
(PubMed) Nishiyama S, Mikeda T, Okada T, Nakamura K, Kotani T, Hishinuma A
