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Indeed the upregulation of NRF2 (nuclear factor, erythroid-derived 2-like 2 factor) has been observed in a wide array of tumors including breast, ovarian, prostate, skin, lung and pancreas [32,44]

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It also increases the levels of Ghrelin in the stomach which helps to controls hunger

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Nectin cell adhesion molecule-4 (Nectin-4), a 66 kDa transmembrane protein belonging to the Nectins family, plays a crucial role in cellcell adhesion, actin cytoskeleton remodeling, and the induction of epithelial-mesenchymal transition (EMT), which ultimately contribute to tumor development and metastasis