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doi:10.1080/009841000156510

Metformin did not exhibit any beneficial effects on the antioxidant system or inflammation in this context

Thus, excess iron is one of the inducers for the activation of apoptosis, necroptosis, and pyroptosis, while ferroptosis is initiated by iron-dependent LOXs and propagated by the iron-driven Fenton reaction

doi: 10.1371/journal.pbio.0020333 49 LiK.HeinS.ZouW.KlugG

Fatigue assessment Patient fatigue was evaluated using both a numerical rating scale (NRS) and our own original fatigue scale, as reported elsewhere 29,30,31,32,54