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Exposure to a number of stressors, including electrophiles, reactive oxidative species, heavy metals, and xenobiotics leads to conformational changes in Keap1, enabling stabilization and nuclear accumulation of Nrf2, where it coordinates the expression of multiple cellular defense enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), and key components of the glutathione (GSH) and thioredoxin (TXN) antioxidant systems 2

With the changing epidemiology of hepatitis-A infection, vaccination to prevent the infection should be given to all children

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doi: 10.1016/j.intimp.2025.114941 86 FornaiFRuffoliRGiorgiFSPaparelliA

doi: 10.3322/caac.21208 521 DetillonDDVeenEJ