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Any stomach disorders, or conditions like pernicious anemia where Intrinsic Factor is lacking, can prevent B12 absorption, as can intestinal inflammation such as Crohns disease if a damaged terminal ileum cannot take up vitamin B12
doi: 10.3390/ijerph18031066

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In a 2022 randomized, double-blind study, researchers assessed the efficacy of topical silymarin versus 2% hydroquinone cream as a melasma treatment

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