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At the pathophysiological level, it is now clear that most narcolepsy cases with cataplexy, and a minority of cases (530 %) without cataplexy or with atypical cataplexy-like symptoms, are caused by a lack of hypocretin (orexin) of likely an autoimmune origin

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A meta-analysis study was conducted by Luigina Guasti et al

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[52] A 2013 meta-analysis of 20 different studies concluded that thiamine supplementation can also improve cardiac function in patients with heart failure, [53] which is a great illustration of how energy insufficiency at the cellular level (in the form of ATP deficiency) produces disease in myriad forms