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A mutated version of this gene is found in a number of small dog breeds

Moreover, each of these aspects is influenced by different processes, such as oxidative stress

For instance, individuals with the PiZZ genotype, associated with severe A1AT deficiency (A1ATD), have been found to have higher iron and ferritin values compared to those with the PiMM genotype

These approaches measure effects across a range of biological pathways simultaneously and can be used to investigate a chemicals mode of action, predict toxicological effects, characterize dose response relationships, and understand species relevance