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These modifications dramatically reduce binding to IGF binding proteins (IGFBP-1 through IGFBP-6), increasing the proportion of bioavailable peptide for receptor interaction in cell-culture systems

It is recognized that (natural) compounds that apply specific frequencies and amplitudes to biological oscillators prevent physiological dysfunctions ordiseases [1](e.g., reducing inflammation)

Current agents (such as nonabsorbable disaccharides and oral antibiotics) are often only partially effective and associated with unpleasant side effects

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