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Some medications also slow metabolism or intensify alcohols effects

However, evidence for a consistent association between BCAA levels and lung function parameters such as FEV 1 and FEV 1 /FVC remains insufficient, requiring validation in larger-scale and longitudinal cohort studies (106)

More recently, however, another polymorphic genotype has been reported that results in ultrarapid metabolism of relevant drugs due to the presence of 2D6 allelic variants with up to 13 gene copies in tandem

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One route involves the hydrolysis of cytoplasmic CE by neutral cholesterol esterase and the resulting free cholesterol is mobilized away from the ACAT pool (72,73) and made available for efflux via ABCA1, ABCG1, SR-BI, and aqueous diffusion (Figure 2)