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It modulates over 4,000 genes involved in tissue remodeling, suppresses pro-inflammatory cytokines (IL-6, TNF-alpha), and activates proteasome and antioxidant pathways (Pickart et al., BioMed Res Int, 2012)

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(102) reported elevated IGF-I levels in 40% of patients with pituitary and adrenal Cushings syndrome

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The exercise-induced ROS generation results in increased activity of enzymatic antioxidants, which then lead to an increased resistance to oxidative challenges, including a wide variety of oxidative stress-related diseases, including cardiovascular diseases, acquired neurodegenerative disorders (Alzheimer's and Parkinson's disease), asthma, diabetes and mitochondrial myopathies