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All cells were obtained from ATCC, except for wt and bax/bak / BMK cells which were a kind gift of Dr

Increased superoxide production was observed in all layers of the vascular wall, namely the endothelium, media and adventitia, 14 and may also increase vasoconstrictor tone via stimulation of the expression of endothelin-1 in the smooth muscle and endothelial cell layer

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