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This aligns with the fact that overexpression of PPAR coactivator 1-alpha (PGC-1), a regulator of mitochondrial biogenesis, increases the generation of CD8 central memory T cells and, in general, improves murine immune responses following infection, immunization, and in the generation of antitumor immunity (131)

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More interestingly, exogenous copper can promote ferroptotic cell death, but not Cuproptosis, by directly binding to GPX4 and further increasing GPX4 degradation [176]

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Based on the pathogenesis of blue light damage, anti blue light damage drugs can include free radical scavengers, antioxidants, anti-inflammatory drugs, and gene therapy (Pan et al., 2023)

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NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma

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Oxidative modification of lens crystallins by H 2 O 2 and chelated iron

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