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ERR is a nuclear receptor that shares significant DNA sequence homology with ER, although E2 is not considered its endogenous ligand 51

Research has shown that sustained rise of IGF-1 levels can suppress growth hormone release through negative feedback at the hypothalamic and pituitary levels

Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies

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Meanwhile, cGAS-STING senses mitochondrial DNA (mtDNA) released from damaged mitochondria during ferroptosis and drives the production of type I interferons (IFN-I), thereby regulating expression of TfR1 and recruiting immune cells to intensify tissue injury (132, 133)