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A seminal study published in Science demonstrated that plasma from exercised aged mice transfers enhanced adult hippocampal neurogenesis and cognition to sedentary aged recipients, identifying the liver enzyme GPLD1 as a key mediator whose systemic elevation recapitulates these benefits without entering the brain [32]
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doi: 10.3389/fphar.2025.1611911 Received 15 April 2025 Accepted 16 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Huanling Lai, Guangzhou National Laboratory, China Reviewed by Wenrui Xia, Chengdu University of Traditional Chinese Medicine, China Wenjun Wang, Hong Kong University of Science and Technology, Hong Kong SAR, China Updates Copyright 2025 Liu, Mu, Qi, Li and Hu

& Segner, H
3.2.1 Quercetin and apoptosis Apoptosis is a form of programmed cell death characterized by specific morphological and biochemical changes such as cell shrinkage, membrane blebbing, chromatin condensation, DNA fragmentation, and caspase activation (Shi, 2004)
