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The shape of a protein determines its function, and they are fine tuned to homeostasis conditions

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Prescriber's Guide: Stahl's Essential Psychopharmacology (6th ed.)

[144] [143] Consequently, FosB is the most significant factor involved in both amphetamine addiction and amphetamine-induced sexual addictions, which are compulsive sexual behaviors that result from excessive sexual activity and amphetamine use
