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This variability makes direct comparisons difficult and contributes to inconsistencies in reported outcomes

PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor, PHA-665752 inhibited c-Met tyrosine phosphorylation at the activation loop (pY1230/34/35), multifunctional docking site (pY1349), and the juxtamembrane domain (pY1003) at 0.1 M [80]

Liu, C., Jiang, L., Liu, L., Sun, L., Zhao, W., Chen, Y., et al., Front

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