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For frozen shoulder specifically, relaxin-2 targets the actual pathology more directly than any other peptide, though availability remains limited

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found that curcumin attenuated IH-induced neuroinflammation and cerebral edema, which was achieved by inhibiting astrocyte aquaporin 4 (AQP4) expression and activating the p38 MAPK pathway (Wang et al., 2018)

[DOI] [PubMed] [Google Scholar] 254.Berens S, Engel F, Gauss A, Tesarz J, Herzog W, Niesler B, Stroe-Kunold E, Schaefert R

In the majority of AD-GTPCHD patients, a moderate to excellent effect on dystonia and tremor was noted