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Obesity alters gut microbial ecology

This overview is intended to contextualize existing findings, without suggesting subtype-specific therapeutic applications (Table 1)

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Oral D-4F reduces atherosclerosis in Apo E-deficient and LDLR-deficient mice, significantly increasing cholesterol emigration from mouse macrophages by mediating cellular signal transduction 146
A separate Phase II study using 0.16 mg/kg subcutaneous injections across three 10-day cycles over 3 months reported significant melanin density increases by reflectance spectroscopy, with the largest gains in the fairest-skinned subjects (Barnetson et al., 2006)
