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ROS are indispensable for processes such as sperm capacitation, hyperactivation, and the acrosome reaction, which are essential for successful fertilization (5, 6)

Neurology 37 , 589596 (1987)

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Certain antioxidants that remain unreactive with Fe 3 -based reagents, such as FRAP, or Fe 3 to Fe 2 transformation methods (e.g., thiols), are effectively oxidized by the CUPRAC reagent

The selective mechanism that avoids systemic hormonal disruption suggests potential for extended use compared to interventions that create metabolic or endocrine imbalances requiring periodic breaks