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This interaction between PD-L1 and PD-1 is known as an immune checkpoint pathway and serves as the target for immune checkpoint inhibitors 45

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To investigate how we could resolve this issue by optimizing the structure, we synthesized seven additional analogs of the most biochemically potent compound, 14 , with modifications on R1 through R5 (Fig

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NbCu/Zn-SOD-1 was primarily localized in the cytoplasm
