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Using in vivo and ex vivo ischemia-reperfusion models, ozone treatment was shown to reduce myocardial injury by regulating ferroptosis-related proteins and transcription factors, particularly enhancing Nrf2 nuclear translocation, thereby exerting cardioprotective effects ( 3.1.5 Mechanisms of ferroptosis in myocardial ischemia-reperfusion injury In pathological conditions such as myocardial ischemia-reperfusion injury, the Nrf2/Keap1 pathway becomes dysregulated, leading to the dissociation of Nrf2 from Keap1 and its subsequent translocation into the nucleus

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Carotenoids, linus pauling institute, oregon state University, Accessed 5 Dec 2024 Higdon J, Drake VJ, Delage B, Traber MG (2024) Vitamin E, Linus Pauling Institute, Oregon State University, Accessed 5 Dec 2024 Hjelmeland AB, Patel RP (2019) SOD2 acetylation and deacetylation: another tale of Jekyll and Hyde in cancer