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Theres also the question of off-target signaling: any peptide touching cytokine networks and survival pathways raises theoretical concerns about interaction with cancer biology, though theres no direct evidence of tumor promotion at this point

Tanaka D, Kagari T, Doi H, et al

Drew Timmermans, ND, a naturopathic physician and cofounder of Regenerative Performance in Arizona, notes the limited but encouraging research

Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit

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