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Furthermore, the expansion of the targeted treatments into broader health concerns, such as reducing the risk of dementia, has broadened their appeal

Saukkonen T, Shojaee-Moradie F, Williams RM, Amin R, Yuen KC, Watts A, Acerini CL, Umpleby AM, Dunger DB
The idea that if a drug is displaced from plasma proteins it would increase the unbound drug concentration and increase the drug effect and, perhaps, produce toxicity seems a simple and obvious mechanism

While not every child responds the same way to supplementation, the research shows that a trial of methyl B12 may be worth consideration.
Concentration can be precisely controlled, and you can easily reduce exposure by diluting or decreasing application frequency
