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Depletion of beneficial taxa such as Odoribacter (Bacteroidetes) and Lachno Clostridium (Firmicutes), along with increased abundance of pro-inflammatory taxa including Ileibacterium and Olsenella , was associated with reduced SCFA gene expression, downregulation of tight junction proteins (occludin and claudin-1), and microglial activation in the amygdala and arcuate nucleus, indicating gut barrier disruption and neuroinflammation that coincided with anxiety-like behavior

10.1007/s00299-023-03091-w 111 SkoutaR.DixonS

This is a pharmacokinetic modification that enables the peptide to bind to albumin, one of the primary transport proteins in the bloodstream

PMCID: PMC2980962

SinghRBWanderGSRastogiAShuklaPKMittalASharmaJPet al