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We find that, although GSH cannot protect against pink-1 or pdr-1 loss-of-function in the context of -synuclein alone, the joint additive neurodegenerative phenotype of both pink-1 and pdr-1 was partially rescued by GSH (Figure 4f) to a degenerative state reminiscent of loss of pink-1 or pdr-1 alone

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Clinical studies also showed that the selective 5-HT 3 antagonist, ondansetron, reduced the incidence and severity of antipsychotic-induced EPS in the schizophrenia treatment (Zhang et al., 2006

doi: 10.1097/00004836-199112002-00005

[12] Kurkin DV, Bakulin DA, Morkovin EI, Kalatanova AV, Makarenko IE, Dorotenko AR, Kovalev NS, Dubrovina MA, Verkholyak DV, Abrosimova EE, Smirnov AV, Shmidt MV, Tyurenkov IN