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repeat daily if required

Hexachlorophene was an extensively used bisphenol that was mainly applied as an antiseptic agent in personal care products (Marzulli and Bruch, 1981) until concerns over its neurotoxicity led to it being banned in the US in 1970s (Heidler and Halden, 2009)

It is also important to note that different conditions affect HbA1c in different ways: Haemolytic anaemia and acute blood loss shorten red cell lifespan and tend to lower HbA1c Iron deficiency anaemia is associated with increased HbA1c, likely due to prolonged red cell survival Haemoglobin variants (haemoglobinopathies) can cause variable or assay-dependent interference the effect depends on the specific variant and the HbA1c method used B12 or folate deficiency alters erythropoiesis and red cell indices, making HbA1c potentially unreliable in either direction Clinicians should therefore: Review the full blood count (FBC) alongside HbA1c Check serum B12 and folate when anaemia or macrocytosis (raised mean corpuscular volume, MCV) is identified Consider alternative glucose assessment methods specifically fasting plasma glucose or a 75 g OGTT for diagnostic purposes, or self-monitored blood glucose (SMBG) or fructosamine/glycated albumin for interim monitoring when HbA1c is unreliable Not sure where to start

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Circ Res 116:15611578 Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Jagic V, Turkovic B, Rotkvic I, Mise S, Zoricic I et al (1997) Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats