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Hence, despite some preliminary evidence is available supporting the use of antimicrobials in the clinical management of BD, further studies are warranted to evaluate the effects of antimicrobials in the gut microbiota and its association with clinical outcomes in these patients

Although its validity as a marker of BBB disruption has been questioned [77], meta-analyses have reported that schizophrenia patients have higher serum S100B concentrations than controls [78,79] and that there is a positive correlation between S100B levels and positive symptoms, total psychopathology scores, and duration of psychotic illness [79]

Nat Rev Immunol 17(2):8396

S., Londono, J
