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The power to detect differences between the study groups is larger than what is projected here as we will measure most of the outcomes more than once and also use these repeated measurements in the same analyses, adjusting for interdependence within a child using mixed effects models, generalised estimating equations or other appropriate methods

We check if its pitting or not, and where it is

Landmark roughly two to three finger-widths below the acromion process, into the densest part of the muscle, well clear of the shoulder bursa

This would remove an enormous financial and time burden from the NHS, and GP Practices and would allow the panic to, at least partially, subside in hundreds of thousands of people in the UK