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Description
An 8-week treadmill exercise at 70%85% VO 2 max significantly downregulated the levels of TFR1, TF, DMT1, FTL, FTH, mitochondrial Ferritin, -secretase, and APP in the cortical motor regions of aged amyloid precursor protein-C105 (APP-C105) mice, upregulated the expression of FPN1, Furin, and -secretase, significantly reduced Fe 2+ , Fe 3+ , and total iron content, inhibited brain iron accumulation and A plaque growth, thereby improving learning ability, memory, and cognitive function in aged APP-C105 mice (Choi et al., 2021)
Res Dev Disabil 35(6):12281236
Preference was given to peer-reviewed original research, clinical trials, and systematic reviews
doi: 10.1002/alz.095298 88
Statistical Analysis
