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Description
Dual Angiopoietin-2 and VEGFA Inhibition Elicits Antitumor Immunity that Is Enhanced by PD-1 Checkpoint Blockade
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Psychoneuroendocrinology 19, 313333 (1994)
The active compound is tirzepatide, a synthetic peptide that acts as a dual agonist at both the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R)
As an overwhelming amount of stable conformers was expected to be found by the CREST procedure, the TDDFT calculations were performed for the first 20 lowestenergy conformers
