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MPTP, a neurotoxin, can freely cross the bloodbrain barrier (BBB) and induce PD (PD)-like phenotypes by selectively damaging dopaminergic neurons (Schmidt and Ferger, 2001)

Cartilage destruction is considered a hallmark of OA and is a result of increased production of catabolic effectors 32,33,34,35 and reduced matrix biosynthesis by chondrocytes 36

Fujita H, et al

There is a need for comprehensive risk assessments and safety regulations to mitigate adverse reactions in humans and animals (58)

These results strongly suggest that selenomethionines regulation of GPX4 is not essential for its ferroptosis-inhibitory function