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2 Chemistry, sources, and pharmacokinetics of luteolin 2.1 Chemical structure and classification Luteolin represents a naturally occurring flavone that is part of the broader class of polyphenolic flavonoids

Abbreviations 1D one-dimensional 2D two-dimensional 2DFT two-dimensional Fourier transform AD Alzheimers disease ACC anterior cingulate cortex AP anterior-posterior ATP adenosine triphosphate BIR-4 B1-insensitive rotation type 4 CHE chronic hepatic encephalopathy Cho Choline COSY correlation spectroscopy C-PRESS Carr-Purcell PRESS Cr Creatine CRLB CramerRao Lower Bounds CT-COSY constant-time correlation spectroscopy CV coefficient of variation EAAT excitatory amino acid transporters EPI echo planar imaging FID free induction decay FOV field of view GABA -aminobutyric acid GAMMA general approach for magnetic resonance mathematical analysis Gln Glutamine Glu Glutamate GluCEST Glu C hemical E xchange S aturation T ransfer Glx Glutamine+Glutamate GM gray matter GRAPPA Generalized Autocalibrating Partially Parallel Acquisitions HE hepatic encephalopathy GSH Glutathione INEPT insensitive nuclei enhanced by polarization transfer ISIS image-selected in vivo spectroscopy JPRESS J-resolved spectroscopy LASER localization by adiabatic selective refocusing LCModel linear combination of model spectra mI myoinositol mM millimolar MRS magnetic resonance spectroscopy MRSI magnetic resonance spectroscopic imaging ms millisecond MS multiple sclerosis NAA N-acetylaspartate NEX number of excitations PEPSI Proton Echo-Planar Spectroscopic Imaging ppm parts per million PRESS Point resolved spectroscopy ProFit Prior-Knowledge Fitting RF radio frequency SAGA Swift Acetate Glial Assay SAR specific absorption rate SENSE Sensitivity Encoding SNR signal-to-noise ratio STEAM stimulated echo acquisition mode T1 longitudinal relaxation T2 transverse relaxation tCho total choline TE echo time tCr total creatine TR repetition time WM white matter References 1.Govindaraju V, Young K, Maudsley AA

Peptides are powerful but work gradually through natural physiological mechanisms

Neuropeptide Y gene polymorphisms and chronic kidney disease progression