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In a reproductive and developmental toxicity study, 0.06 mL of a vaccine formulation containing the same quantity of nucleoside-modified messenger ribonucleic acid (modRNA) (30 mcg) and other ingredients included in a single human dose of Pfizer-BioNTech COVID-19 Vaccine was administered to female rats by the intramuscular route on 4 occasions: 21 and 14 days prior to mating, and on gestation days 9 and 20

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Behavioral data were analyzed by analyses of variance (two- or three-way with repeated measures as appropriate), followed by post hoc analyses using Fishers least significant difference test

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They show some positive effects on sleep quality, such as restful sleep, but they dont show that melatonin supplements reverse the cognitive deficits of AD.[ref] One placebo-controlled trial of six months of 2mg time-release melatonin in people with mild to moderate AD did show positive results on cognitive performance compared to placebo