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Compared to silibinin, these derivatives provide superior solubility, enhanced biological activity, and exert their anti-cancer effects through diverse mechanisms, including targeted cell cycle arrest and induction of apoptosis

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Anim Sci J 92:e13540 Sayed AM, Hassanein EHM, Ali FEM, Omar ZMM, Rashwan EK, Mohammedsaleh ZM, Abd El-Ghafar OAM (2021) Regulation of Keap-1/Nrf2/AKT and iNOS/NF-B/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: mechanistic insights and computational pharmacological analysis

doi: 10.1016/j.jep.2024.119160 55 WangQ.QiB.ShiS.JiangW.LiD.JiangX.et al