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doi: 10.1016/j.gene.2019.144077

Clinical studies have confirmed a significant positive correlation between serum uric acid levels and insulin resistance indices, indicating that uric acid-lowering therapies can improve insulin sensitivity to some extent

Some researchers have used this finding together with the failure of AChEIs to cure AD as a reason to invalidate the cholinergic hypotheses and shifted their attention towards mutations of APP genes, tau protein production, and A depositions as the more likely causative factors 29,30