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Anim Reprod Sci 2014;146:5562

The coordinated and precise interaction between the ubiquitin-proteasome system (UPS), the protein chaperone system, and the autophagy-lysosome system (ALS) results in a dynamic endogenous protein quality control system that is essential to ensure the protein homeostasis 4,5,6

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It has been recognized that exercise training triggers an increase in NO production, Ca 2+ -calmodulin kinase interaction, and adenosine monophosphate-activated protein kinase (AMPK) activation, which leads to PGC1 upregulation and activation in both skeletal and cardiac muscle cells

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