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Abstract Thyroid eye disease (TED) is a disfiguring autoimmune disease characterized by changes in the orbital tissues and is caused by abnormal thyroid function or thyroid-related antibodies

Khuri FR, Lee JJ, Lippman SM, Kim ES, Cooper JS, Benner SE,

10.3390/biom12020336 244 YenH.-C.LiuY.-C.KanC.-C.WeiH.-J.LeeS.-H.WeiY.-H.et al

Clinical trials show that 25 to 40 percent of patients experience nausea during the first two weeks, but this typically resolves by week three or four as the body adapts

Furthermore, inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) each attenuated renal fibroblast proliferation and collagen production, suggesting the mechanistic role for each in mediating the effect of TMAO on renal fibroblast proliferation